Levodopa and subthalamic deep brain stimulation responses are not congruent
Identifieur interne : 000661 ( Main/Exploration ); précédent : 000660; suivant : 000662Levodopa and subthalamic deep brain stimulation responses are not congruent
Auteurs : Adam Zaidel [Israël] ; Hagai Bergman [Israël] ; Ya'Acov Ritov [Israël] ; Zvi Israel Md [Israël]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-10-30.
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Abstract
There is a consensus that in Parkinson's disease, the extent of preoperative levodopa responsiveness predicts the efficacy of subthalamic nucleus deep brain stimulation (STN DBS). However, this may be the result of statistical methods and primary assumptions. We were able to reproduce previously published correlation results on our data (N = 49 patients). Yet, these same results were demonstrated even after random shuffling of our data. Notably, we did not observe a correlation between STN DBS efficacy and preoperative levodopa responsiveness when using their respective baselines and fractional scores of motor improvement. Furthermore, postoperative responses were not limited by preoperative scores, with tremor demonstrating the greatest discrepancy. We conclude that preoperative levodopa responsiveness does not predict or limit the outcome of STN DBS. These results imply different therapeutic mechanisms for levodopa and STN DBS and therefore question the validity of using substantial preoperative levodopa responsiveness as a selection criterion for STN DBS. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.23294
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-10-30">2010-10-30</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">14</biblScope><biblScope unit="page" from="2379">2379</biblScope><biblScope unit="page" to="2386">2386</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">40F812414774F02DADD69780FA164044D49897E3</idno><idno type="DOI">10.1002/mds.23294</idno><idno type="ArticleID">MDS23294</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>basal ganglia</term><term>deep brain stimulation</term><term>levodopa</term><term>predictive factor</term><term>subthalamic nucleus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is a consensus that in Parkinson's disease, the extent of preoperative levodopa responsiveness predicts the efficacy of subthalamic nucleus deep brain stimulation (STN DBS). However, this may be the result of statistical methods and primary assumptions. We were able to reproduce previously published correlation results on our data (N = 49 patients). Yet, these same results were demonstrated even after random shuffling of our data. Notably, we did not observe a correlation between STN DBS efficacy and preoperative levodopa responsiveness when using their respective baselines and fractional scores of motor improvement. Furthermore, postoperative responses were not limited by preoperative scores, with tremor demonstrating the greatest discrepancy. We conclude that preoperative levodopa responsiveness does not predict or limit the outcome of STN DBS. These results imply different therapeutic mechanisms for levodopa and STN DBS and therefore question the validity of using substantial preoperative levodopa responsiveness as a selection criterion for STN DBS. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Israël</li></country></list><tree><country name="Israël"><noRegion><name sortKey="Zaidel, Adam" sort="Zaidel, Adam" uniqKey="Zaidel A" first="Adam" last="Zaidel">Adam Zaidel</name></noRegion><name sortKey="Bergman, Hagai" sort="Bergman, Hagai" uniqKey="Bergman H" first="Hagai" last="Bergman">Hagai Bergman</name><name sortKey="Bergman, Hagai" sort="Bergman, Hagai" uniqKey="Bergman H" first="Hagai" last="Bergman">Hagai Bergman</name><name sortKey="Md, Zvi Israel" sort="Md, Zvi Israel" uniqKey="Md Z" first="Zvi Israel" last="Md">Zvi Israel Md</name><name sortKey="Ritov, Ya Acov" sort="Ritov, Ya Acov" uniqKey="Ritov Y" first="Ya'Acov" last="Ritov">Ya'Acov Ritov</name><name sortKey="Zaidel, Adam" sort="Zaidel, Adam" uniqKey="Zaidel A" first="Adam" last="Zaidel">Adam Zaidel</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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